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The role of TP53 tumour suppressor as a predictor The TP53 tumour suppressor protein is one of the major factors involved in protecting DNA against damage that may occur as a result of internal (e.g. metabolic free-radicals) or external (e.g. smoking) stress. Several in vitro studies on different tumour types, including haematological neoplasms, have shown that sensitivity of tumour cells to chemotherapy or radiotherapy is associated with lack of mutation in the TP53 gene. More than 50% of solid tumours harbour mutations in the gene of this protein. Thus, TP53 mutation status has been evaluated as an indicator for a tumour’s response to treatment, as well as patient’s survival. In fact, many studies on tumours including lymphomas have considered the TP53 mutation status in the analysis of initial response and survival. However, inconsistency in results, due to employing different approaches for detecting TP53 mutation, have failed to provide a reliable diagnostic procedure. |
Why we are slow with predictors?
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Molecular Oncology |
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Why we are slow with predictors? |
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Publication |
